ABSTRACT In-stent restenosis stands out among the late complications of coronary angioplasty. Initially, it occurred in up to 60% of procedures using only balloons, but dropped to 10% with the advent of drug-eluting stents, even in more complex anatomic and technical scenarios. However, efforts have been made to achieve long-lasting results with no need for new revascularizations. Broad knowledge of pathophysiology, of predisposing risks factors for restenosis, and of new concepts, such as neoatherosclerosis, is paramount to its prevention. This […]