J Transcat Intervent.2020;28:eA20190033.
Effects of statin pretreatment on adverse cardiac events following elective percutaneous coronary intervention
Liliane Gatti
, Luisa Superti Dal Magro
, Samara Ezzat Khalil
, Guilherme Gaeski Passuello
, Marcia Olandoski
, José Knopfholz
DOI: 10.31160/JOTCI202028A20190033
ABSTRACT
Background
Identification of risk factors for complications following percutaneous coronary intervention may contribute to appropriate management and reduction of adverse outcomes. The prior use of statins has been associated with lower prevalence of procedure-related myocardial infarction. This study set out to determine the prevalence of periprocedural myocardial infarction in elective coronary interventions, and to identify associated risk factors, with special emphasis on statin pretreatment.
Methods
The sample comprised 249 patients submitted to elective therapeutic percutaneous coronary intervention at a referral interventional cardiology center between 2016 and 2018. Periprocedural myocardial infarction was defined according to Fourth Universal Definition of Myocardial Infarction criteria.
Results
Periprocedural myocardial infarction and injury occurred in 26 (10.4%) and 141 (56.6%) patients, respectively. Male sex was associated with increased event rates (74.2% versus 57.3%; p=0.009). Statin pretreatment was correlated with lower event rates (59.8% versus 74.4%; 95%CI 0.29-0.92; p=0.025). Protective effects of statins remained significant following multivariate analysis accounting for sex and beta-blocker use (OR: 0.37; 95%CI 0.19-0.75; p=0.005).
Conclusion
Periprocedural myocardial infarction and injury are common outcomes following elective percutaneous coronary intervention. Prevalence of such events was lower in patients using statins and higher in male patients. Findings of this study support positive evidence regarding the role of statins in cardiovascular protection.
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